百济神州：港股公告：百济神州有限公司截至2023年12月31日止年度全年业绩公告

查股网 2024-03-29 百济神州(688235)公司公告

BeiGene, Ltd.

0616020231231

202312312022GAAP

?20231231202212311073.7%2520221231

935.274.5%22?2023123120221231

367.512.6%3,286.6

?20231231202212311156.0%881.7

?202312310.65202212311.4956.4%

123120232022

3,171,8003,869,564 411,473196 52,600665,251 6358,027173,168 7416,122282,346 12243,392216,553

4,203,4145,207,078

91,324,154845,946 895,207109,960 1057,13840,616 12125,362175,690

1,601,8611,172,2125,805,2756,379,290

13315,111294,781 12693,731467,352 3–213,861 1122,95125,189 821,95024,041 368,004114,335 14688,366328,969

1,810,1131,468,528

123120232022

14197,618209,148 330042,026 822,25134,517 1116,49415,996 3170,662179,625 1250,51046,095

457,835527,4072,267,9481,995,935

0.0001 9,500,000,0002023 20221231 1,359,513,224 1,356,140,180135135 11,598,68811,540,979 19(99,446)(77,417) (7,962,050)(7,080,342)

3,537,3274,383,3555,805,2756,379,290

123120232022

152,189,8521,254,612 3268,927161,309 2,458,7791,415,921

379,920286,4752,078,8591,129,446 1,778,5941,640,508 1,504,5011,277,852 103,500751 3,286,5952,919,111

(1,207,736)(1,789,665) 74,00952,480 5307,891(223,852)

(825,836)(1,961,037)1155,87242,778

(881,708)(2,003,815)17(0.65)(1.49)171,357,034,5471,340,729,572

(8.45)(19.43)

104,387,273103,133,044

123120232022

(881,708)(2,003,815) 19(25,464)(90,421) 22(5,611)365 199,046(5,311)

(903,737)(2,099,182)

123120232022

(881,708)(2,003,815) 87,67566,278 18367,618303,162 346,80068,665 3(55,294)(96,402) 516,22121,996 6892,059

20(362,917)– (5,998)9,047 (188,306)304,112 (140,948)(56,689) 12,120(3,282) 21,484(4,352) 180,11145,627 (255,587)(151,816) 587(1,209)

(1,157,453)(1,496,619)

(561,896)(325,434) (2,075)(1,485) 673,2401,563,618 (15,000)(143,665) 10(19,365)– 5(14,900)(15,911)

60,0041,077,123

123120232022

1422,50237,372 14661,530313,774 14(323,266)(417,081) 55,71246,964

416,478(18,971)(8,082)(69,383)(689,053)(507,850)3,875,0374,382,8873,185,9843,875,037

3,171,8003,869,564 11,473196 2,7115,277 56,00329,500 19,75325,169

91,80495,346 31,800–

202112311,334,804,28113311,191,00717,950(5,076,527)6,132,563 ––(152)––(152) 1,375,621–––––

19,960,278246,962––46,964 ––303,162––303,162 –––(95,367)–(95,367) ––––(2,003,815)(2,003,815)202212311,356,140,18013511,540,979(77,417)(7,080,342)4,383,355 84,227–––––

26,561,925253,006––53,008 (23,273,108)(2)(362,915)––(362,917) ––367,618––367,618 –––(22,029)–(22,029) ––––(881,708)(881,708)202312311,359,513,22413511,598,688(99,446)(7,962,050)3,537,327

202325202210

?(BTK)

?PD-1

?PARP1PARP2

???

CRO

3,000CRO1304522,000

CMO201010,000

20231231

2,722,787,023

100%

14,530,380,600

100%*

1,434,344,311

100%*

4,273,218,389

100%

*1,000,000100%*

620,000,000

100%BeiGene USA, IncBeiGene USA

1100%BeiGene AUS Pty Ltd

BeiGene Australia

56,947,230100%BeiGene Switzerland GmbHBeiGene Switzerland

20,000100%BeiGene Hopewell Urban Renewal,LLC

507,943,128100%*

2023112023-072802023121520241215

2023122023-09740

(1)(2)

5%(3)

20241215

20231231

202320221231

12312023202279,43146,822104,477104,99471,980–13,0399,493268,927161,309

20211

650,000,0001,300,000,000250,000,000

(1)(2)(3)

650,000,000

484,646,000165,354,000

20211231

20239

202320221231

12312023202272,27839,655

(1)

5,0679,49377,34549,148(1)

202112

TIGIT?????

2022

20221300,000,000202320232023

600,000,000700,000,000

745,000,0001,150,000,000

50%25%

(1)(2)

(3)(4)

300,000,000

(i)

(ii)

71,980,000213,450,000

14,570,000

20237

202320221231

1231202320227,1537,167104,477104,99471,980–(2)

8,859–192,469112,161(2)

201910

???

202012

???

?201920201120207

?202012

?R/RBALL20217

?R/R20224

CD19B

1,250,000,000KRAS G12CLUMAKRAS (sotorasib)AMG 510AMG 510

2022420

LUMAKRAS20232(i)2023112023831LUMAKRAS

(ii)LUMAKRAS

100%

20191031202012174.8515,895,00120.5%Anthony Hooper2020120231

132.742,109,902,000

601,857,0002,779,241,0002,162,407,000616,834,000

202320221231

12312023202253,31498,95555,29496,402108,608195,357

20231231

483,651202320221231

12312023202268,004114,335170,662179,625238,666293,96020231231

1231202320228,3585,898(60,917)(54,865)1,688(1,216)(50,871)(50,183)202320221231108,691,00071,720,00020232022123155,474,00054,064,000

202320221231

12312023202246,80068,665

–5,50024,365–71,16574,165

202311

22024130,000,000

1,300,000,000

20231231

202212

LY0100520221248,665,00030,000,0002023123119,365,000Shoreline Biosciences, Inc.

20216Shoreline BiosciencesInc.ShorelineShoreline

ShorelineShorelineShorelineShoreline2022145,000,000

20211231

Shoreline2024

202112

LBL-007LAG-3

2022130,000,000742,000,000

20211231EUSA Pharma20201EUSA PharmaEUSA

βEUSA

??EUSA40,000,000

120,000,000202012312021??EUSA

?Assembly Biosciences, Inc.20207Assembly Biosciences, Inc.AssemblyAssemblyAssemblyABI-H0731ABI-H2158ABI-H3733AssemblyAssembly40,000,000

503,750,000Assembly

20201231202312Assembly

20208?(BAT1706)

20209102020918

20201020,000,000145,000,00020201231202111

?2023125,000,000

202320221231

2023202212

12312023202211,4731962,7115,27714,1845,473

202312311,191,583,000

20231231

2,56535–2,6002,56535–2,600

20221231

674,262–9,011665,251674,262–9,011665,2512023123120231231

20231231

Leap Therapeutics, Inc.

20201Leap Therapeutics, Inc.Leap

5,000,000Leap BB20203LeapLeap20219Leap7,250,000

Leap20231231Leap

2.9%

4.7%

Leap

12312023202242530,102202320221231

123120232022Leap3,0463,307Leap542706

20232022123155,860,00057,054,000

123120232022(6,448)5,065

20232022123125,981,00027,710,000

1231202320227,8563,682

123120232022360,053173,379(2,026)(211)358,027173,16830120

1231202320226356,243172,6336121,784535

358,027173,168

12312023202211211415

1,861(219)

(43)–

(3)15

12312,026211

123120232022148,77288,957

39,09820,886228,252172,503416,122282,346

503630

123120232022

25,97825,9386,1016,8341,6831,299

33,76234,071

12312023202243,49056,00851,71753,95295,207109,96021,95024,04122,25134,51744,20158,558

2024123123,4992025123114,148202612315,740202712313,155202812311,682

49,156(4,955)44,201

12312023202227,98528,06411,85422,278

123120232022

7.22%5.76%

12312023202265,48565,485205,349158,908

60,12453,786231,656222,448186,856175,679

83,28147,483832,751723,789(249,212)(171,470)

740,615293,6271,324,154845,946202320221231

123120232022

579,649224,392119,38033,33216,13512,25625,45123,647740,615293,62720232022123180,436,00062,302,000

10.

202320221231

2023123120221231

64,274(7,807)56,46741,235(4,119)37,1168,987(8,316)6718,316(4,816)3,50073,261(16,123)57,13849,551(8,935)40,616

1231202320223,7393,2253,5007517,2393,97620231231

123120244,7762245,00020254,7762245,00020264,7762234,99920274,776–4,77620284,776–4,776202932,587–32,587

56,46767157,13811.

123120232022117,44667,744(315,852)(583,610)(627,430)(1,445,171)(825,836)(1,961,037)

123120232022

25,1704,84424,95627,9055,0596,54755,18539,296

6873,480

–26873,48255,87242,778

123120232022(825,836)(1,961,037)

21%21%(173,426)(411,818)141,902209,692

19,13429,22332,58133,872(3,464)1,375845,811229,550(704,928)–

(64,343)(42,844)(37,395)(6,272)55,87242,778(6.8)%(2.2)%

123120232022106,70897,896996,588862,214

26,68719,70068,11786,000704,928–687,600798,5637,89310,348164,19063,156

(7,735)(10,098)2,754,9761,927,779(2,771,470)(1,943,775)(16,494)(15,996)

20231231202320221231

123120232022111,943,7751,758,409

845,811229,550(18,116)(44,184)12312,771,4701,943,7752023202212315,945,753,0005,077,247,00020231231202420331,839,748,000202520304,088,658,0002,047,00076,794,000

20362043704,928,0002028

202320221231

1231202320221111,5559,925

2,7091,630123114,26411,555

2023123112

202320221231

20231231201320232013202320202023

20152023

20132023

2025

202312313,092,000

0.01

202312312,969,000

12.

12312023202260,47671,48837,32020,47836,12422,7771,7353,0398,8723,66442,06658,95056,79936,157243,392216,553

1231202320224,14422,025

(1)

18,12248,642

2,5468048,1957,0542,7115,27789,64491,779

–109125,362175,690(1)

123120232022217,803184,775162,969139,16887,57251,80630,08318,815139,93641,817

55,36830,971693,731467,352

123120232022

34,20438,17614,9957,7601,127–18415950,51046,095

13.

202320221231

1231202320223302,310290,284368,2052,570614,5511,379145548

315,111294,781

14.

202320221231

123120232022201844580,0009202744(1)14,089100,0007,25050,0002020122(2)92029120(2)8,85662,8571,45010,0002020119378,00092029118(3)5,63640,0005,43737,5002023728380,000120241225(4)300,0002,129,321––20231220150,0001202412197.3%150,0001,064,660––2020924200,000(5)––150,0001,034,554202222550,000120232252.2%––50,000344,851202365400,00012024643.2%56,356400,000––202354340,0001202453(6)47,903340,000––2023530200,000120245292.8%28,177200,000––20231114700,0001202411212.9%49,312350,000––

(7)28,037199,000114,832792,000

688,3664,885,838328,9692,268,905201844580,0009202744(1)59,174420,00075,395520,0002020122(2)92029120(2)37,638267,14347,847330,0002020119378,00092029118(3)42,337300,50049,369340,5002022729480,000102032728(8)58,469415,00036,537252,000

197,6181,402,643209,1481,442,500

1. 20231231

4.5%202312316,987,00050,000,000

2. 2020122

1,100,000,000202112311,100,000,000350,000,000202312

314.1%202312311,422,000

10,000,000201733

3. 20231231

3.9%

202312315,281,00037,500,000

4. (SOFR)202312

317.2%

5. 20209200,000,000

120,000,00080,000,000

2021108202110820221082022930

20231231150,000,000

6. 202312

314.5%

7. 20231231

875,000,0002022121520245242023123128,174,000

199,000,000109,576,000792,000,000202312313.2%20245

8. 20227

480,000,000202312313.9%2023123122,502,000163,000,000

20231231

20241231688,3662025123135,5652026123146,2792027123146,2792028123125,146

44,349885,984

20232022123120,800,00021,699,00016,571,0002,594,000

15.

??????

???

202320221231

1231202320222,718,9691,438,440

(529,117)(183,828)2,189,8521,254,612202320221231

123120232022?

1,290,396564,651?

536,620422,885?

76,01879,049

92,82863,398

56,54738,124

54,34236,107?

39,79913,696

13,96015,213?

6,6685,460

22,67416,0292,189,8521,254,612202320221231

1231202320221141,81759,639

529,117183,828(430,998)(201,650)1231139,93641,817

16.

123120232022379,920286,475980,43662,302

1,778,5941,640,508825,97825,938107,2393,976 1,120,4031,000,890 18367,588303,162 62,09250,358

1,550,0831,354,41064,760233,81261,861(219)

2,9641,140(78,373)(74,234)

202320221231699,289,000602,585,00017.

123120232022

(881,708)(2,003,815) 1,357,034,5471,340,729,572

(0.65)(1.49)

202320221231

18.2016

20161201620162016265,029,595

201620112011

20162011

20231231

201120165,166,8222016

201711(i)

(5%)(ii)20181129,603,6162016201882016

2018122016

38,553,15920206201657,200,000

2030413201620231231201637,575,472

20162016

201666,300,00020223315%20226222018

201862018201812,000,000

5635(c)(4)5635(c)(4)20182018

201620188

)2018201620182022622

2018

2018620183,500,00020188201812

3,855,3157,355,315

15%

10%

2023831794,144207.5515.97176.4213.5710,7772023228930,582171.1013.16145.4411.1910,4142022831861,315171.6613.20145.9111.229,6672022228667,160210.5216.19178.9413.769,1832021831425,386308.3023.72262.0620.168,5752021226436,124236.3018.18200.8615.456,738

202312311,941,075

201120162018

2021123172,204,8887.08 12,516,81612.346.40 (5,898,217)4.6352,258 (2,296,634)16.462022123176,526,8537.85 9,817,92516.378.14 (6,974,331)4.5492,051 (1,225,334)17.60

2023123178,145,1139.065.09465,231

2023123159,221,0916.933.91452,750

2023123175,306,5108.814.95463,359

2023123116,085,419

96,053,0002.520232022123161,121,00062,548,000

123120232022

7.26~ 10.725.51~ 9.04

3.4% ~ 4.6%1.8% ~ 3.9%

2.82.858% ~ 60%51% ~ 60%

0%0%1010

20232022123120231231

20162018

2021123136,082,98218.33 38,707,66912.46 (12,533,586)16.37 (6,859,892)16.722022123155,397,17314.87 34,573,99415.57 (17,862,598)14.71 (5,707,546)15.472023123166,401,02315.222023123156,440,87015.22

20231231702,778,0002.8

202320221231

123120232022163,550139,348204,038163,814367,588303,162

19.

2021123127,898(3,700)(6,248)17,950

(90,421)(5,311)(446)(96,178)

(1)

––811811(90,421)(5,311)365(95,367)20221231(62,523)(9,011)(5,883)(77,417)

(25,464)9,046(6,422)(22,840)

(1)

––811811(25,464)9,046(5,611)(22,029)20231231(87,987)35(11,494)(99,446)(1)

20.

BMS202381BMS-Celgene

ABRAXANE

?20172018BMS-Celgene201723,273,10820231231

202412312023815362,917,00020231231

21.

10%50%

202320221231

10%

2023202212314,125,458,0003,548,881,00022.

20232022123194,358,00083,860,000

401(k)401(k)401(k)401(k)20234%202320221231401(k)15,316,00010,298,000

2023202212312,710,0003,887,000

20232022123170,600,00045,835,000

55,605,00038,075,000

20211231

20233,577,000

20231231

2024123160720251231214202612315802027123198520281231811

9,56912,766

23.

20231231169,212,00041,186,000128,026,000BMS

BMS

20231231333,498,000

1,250,000,00020231231483,651,000

15,055,000202312318,905,000

(CRO)

24.

1231202320221,128,219502,626945,551389,710182,668112,9161,101,951840,0321,093,091840,0328,860–202,01463,257122,22814,86479,78648,39326,59510,00628,98210,006(2,387)–2,458,7791,415,921

25.

20231231

(i)(iii)(1,778,594)(31,745)1,344(1,808,995)(1,504,501)(21,942)1,659(1,524,784)74,009–(3,082)70,927(825,836)(53,687)(79)(879,602)

(55,872)(15,000)–(70,872)(881,708)(68,687)(79)(950,474)

20221231

(i)(iii)(1,640,508)(14,697)471(1,654,734)(1,277,852)(19,296)366(1,296,782)52,480–(3,142)49,338(1,961,037)(33,993)(2,305)(1,997,335)

(42,778)10,311–(32,467)(2,003,815)(23,682)(2,305)(2,029,802)

20231231

(i)(ii)(iii)95,207––(2,384)92,8235,805,275––(2,384)5,802,89111,598,68868,687––12,183,311

208,042*307,894*–(7,962,050)(68,687)–(79)(8,549,057)

(208,042)*(307,894)*(2,305)*3,537,327––(2,384)3,534,943

20221231

(i)(ii)(iii)109,960––(2,305)107,6556,379,290––(2,305)6,376,98511,540,97933,993––12,056,915

174,049*307,894*–(7,080,342)(33,993)–(2,305)(7,598,583)

10,311––

(184,360)*(307,894)*–4,383,355––(2,305)4,381,050*

(i)

20231231

53,687,000202233,993,000

(ii)

20162307,894,000

307,894,000

(iii)

201911

26.

20231231202212

(U.S. GAAP)

(U.S. GAAP)GAAP

GAAPGAAPGAAP

GAAP

GAAPGAAPGAAPGAAPGAAP

GAAPGAAP

GAAPGAAPGAAP

GAAPGAAP

2023

2023? 202325

73.7%

202313128.5%? sonrotoclax

CLL3BTK CDACR/R CLLR/R MCL?

2024314(FDA)

PD-(L)1(ESCC)20231222FDA

(R/R)(CLL)3ALPINE(PFS)20231121

(IND)2(CDK2)

20231117(EC)

?R/R(FL)

20243,500(BD)

1. 3,000

(CRO)75%

1,100

(R/R)(CLL)(PFS)(ORR)BCL-2sonrotoclaxBTK(CDAC)BGB-16673

KRASPRMT5CDK4CDK2B7H3-ADCCEA-ADCB7H4-ADCMUC1× CD16AClaudin6× CD3CDACADCmRNA

?29375,000

800ALPINE?

BTK2022(ASH)?202312(FDA)

R/R CLL3ALPINE(PFS)

?2023

2022

128.5%

?sonrotoclaxBCL2BTK-CDACCLLBPD-1

PD-1/PD-L1

20247ESCC

KRASPRMT5CDK4CDK2B7H3-ADCCEA-ADCB7H4-ADCMUC1×CD16AClaudin6× CD3

4. 3,700500

?2023CLL(SLL)

??BTKPD-1/PD-L1

2023

(EMA)

2023123132

2024

202320221231

123120232022%

2,189,8521,254,612935,24074.5% 268,927161,309107,61866.7%

2,458,7791,415,9211,042,85873.7%379,920286,47593,44532.6%2,078,8591,129,446949,41384.1% 1,778,5941,640,508138,0868.4% 1,504,5011,277,852226,64917.7% 3,5007512,749366.0%

3,286,5952,919,111367,48412.6%(1,207,736)(1,789,665)581,929(32.5)% 74,00952,48021,52941.0% 307,891(223,852)531,743(237.5)%

(825,836)(1,961,037)1,135,201(57.9)%

55,87242,77813,09430.6%(881,708)(2,003,815)1,122,107(56.0)%

202212311420231231

1025

?202320221231

123120232022%2,189,8521,254,612935,24074.5% 71,980–71,980 79,43146,82232,60969.6% 104,477104,994(517)(0.5)% 13,0399,4933,54637.4%

268,927161,309107,61866.7%2,458,7791,415,9211,042,85873.7%

12312023%2022%1,128,21945.9%502,62635.5%

945,55138.5%389,71027.5%182,6687.4%112,9168.0%1,101,95144.8%840,03259.3%1,093,09144.5%840,03259.3%8,8600.3%–%202,0148.2%63,2574.5%122,2285.0%14,8641.0%79,7863.2%48,3933.5%26,5951.1%10,0060.7%28,9821.2%10,0060.7%(2,387)(0.1)%–%2,458,779100.0%1,415,921100.0%

123120232022%

1,290,396564,651725,745128.5%?

536,620422,885113,73526.9%?

76,01879,049(3,031)(3.8)%?

92,82863,39829,43046.4%?

56,54738,12418,42348.3%?

54,34236,10718,23550.5%?

13,96015,213(1,253)(8.2)%?

39,79913,69626,103190.6%?

6,6685,4601,20822.1%

22,67416,0296,64541.5%2,189,8521,254,612935,24074.5%202312312213

20231231

128.5%20231231

9.456

3.897142.6%?

CLLSLL202312

1.93828.9%

20231231

1.2222,880722.3%

194.8%CLLSLLWM

20231231

5.366

26.9%20231231

20231,3202023320241

202312312.6892023

202312317,940

1.045

7,2001,300

202212311.61320221231

4,680

1.05950

20241231

202212312.86520231231

3.799

2023123118

82.7%2022123110

77.2%

20221231161.381

8.4%2023123118202320221231

123120232022%

551,417469,49781,92017.4% 46,80068,665(21,865)(31.8)%

53,31598,955(45,640)(46.1)%651,532637,11714,4152.3%1,127,0621,003,391123,67112.3%1,778,5941,640,508138,0868.4%

1,558,9601,474,91984,0415.7%

1. 202312311.086

5,3305,5302.

GAAPGAAP20231231

Sonrotoclax(BGB-11417)

20221231101.237

12.3%11

123120232022%1,504,5011,277,852226,64917.7%

1,284,6891,077,977206,71219.2%

GAAPGAAP

20221231132.266

17.7%2023123115

202212315,2502,150

41.0%202312317,400

202312313.079BMS3.629

202212312.239

202312315,59020221231

4,28020231231

202112BEPS

GAAP

123120232022GAAPGAAP379,920286,475

8,578–3,7393,225367,603283,250GAAPGAAP1,778,5941,640,508

163,550139,348

56,08426,2411,558,9601,474,919GAAPGAAP1,504,5011,277,852

204,038163,814

15,77436,0611,284,6891,077,977GAAPGAAP3,286,5952,919,111

367,588303,162

71,85862,3023,5007512,843,6492,552,896GAAPGAAP(1,207,736)(1,789,665)

367,588303,162

80,43662,3027,2393,976(752,473)(1,420,225)

20231231(i)13(ii)13018(iii)69.7

20221231173.2106.8%20231231358.0

20221231282.347.4%20231231

416.1

20221231216.612.4%20231231243.4(i)(ii)

20221231845.956.5%202312311,324.2

202320221231

315.1294.8

1231202320223302,310290,284368,2052,570614,5511,379145548

315,111294,781

202320221231

123120232022217,803184,775162,969139,16887,57251,80630,08318,815139,93641,81755,36830,971693,731467,35220221231467.448.4%20231231693.7(i)(ii)(iii)

202212315.38120231231

8.86064.6%

20231231

123120232022

3,185,9843,875,0372,600665,251885,984538,117

2023202212319202023123180

20179

20231231

20231231(BeiGene, Ltd.)8.860

(BeiGene, Ltd.)5.472

20211215PRC

192.60391.68115,055,26034

2023123112

202320221231

123120232022

3,875,0374,382,887(1,157,453)(1,496,619)60,0041,077,123416,478(18,971)(8,082)(69,383)(689,053)(507,850)3,185,9843,875,037

2023123112

8.8173.7059,480

BMS

2022123115

2.2393.748

1.324

202312316,000

6.7325.6191,500

1,9401,490

202212311116

3.2541.4371,590150

202312314.165

6.615

5,5702,250

3.0961,370

20246.884

202212311,900

4.1713.138

4,7003,740

20231231

49,15623,49925,657169,212140,77528,437885,984688,366197,61832,1018,93923,162483,651137,809345,8428,9052,2136,69214,9953,57711,418333,498333,498–1,977,5021,338,676638,826

202312311.692

4,120BMS

1.280BMS

6.8841.976

20231231

12.5

20231231

4.837

1,51020231231890

20231231

202312313.335

7,520202242920231231

5.024

20232022123132391,4205502607

100202312311010

202312315.74120231231100

2023202212313.5801.732

1994PBOC

2005

2023202212312.8%8.2%

20231231

2022123112.3%25.0%

7,520202242920231231

5.024

20231231

2023123110,500202212319,000

2023123116202214

2023123114.220221231

5.5

200.420221231123.9

2023123120221231

20231231

C.2.1

Ranjeev Krishana

3.21

D.3.3D.3.7

Anthony C. Hooper2023417Olivier BrandicourtCorazon (Corsee) D.Sanders2023913Anthony C. HooperThomas MalleyAnthony C. Hooper3.10(2)

3.21Thomas Malley2024122Thomas Malley

2024123Olivier BrandicourtMalleyOlivier Brandicourt

2024123

3.25

E.1.2

Margaret Han DuganRanjeev KrishanaMargaret Han Dugan

3.27AB.3.1

Donald W. GlazerMichael GollerAnthony C. Hooper2023417Alessandro RivaDonaldW. Glazer

B.8

BMS-Celgene23,273,108

2023822023111

13.51(B)(1)

Anthony C. Hooper2023417

2023913

Thomas Malley2023913

2024122

Olivier Brandicourt2024123

2024319

202012

174.8515,895,001206,635,013

20.5%2,779,241,000(a)2019103030

36%(b)1.007.842019103126%(c)

2019103126%

2019112920231231

(%)

20221231

20231231

(a)

2,779,241100%2,080,0682,229,632549,609(a)

12.5

20191129

202620191112019

1292020132020924

20.6%

20.4%75,000,000

2020121(a)20%(b)60(c)

202031820209252020109

20219165,5292,151,87750,000,0002022123150,000,000

20211215

20216162021

192.60

234.89391.68115,055,260

3,392,616,000

(i)(ii)(iii)(iv)(v)20231110

202011162021129202142020215142021612021621202162820216302021792021728202110152021111620211123202111242021112920211130202112220211262021127202112132021122120211228202242920226272022830202292820234252023829202311132021430

2023123113780

20231231

20221231

20231231

13,245,9404,499,8497,169,4706,076,470467,700376,601434,18833,512150,000153,451153,451(3,451)*136,36071,580110,24026,1206,000,0002,662,6744,832,2811,167,7191,630,155489,000978,000652,15521,630,1558,253,15513,677,6307,952,525

Anthony C. Hooper2023417Olivier BrandicourtCorazon (Corsee) D. Sanders2023913Anthony C. HooperThomas MalleyThomas Malley2024122Malley

2024123Olivier Brandicourt

MalleyOlivierBrandicourt2024123

20231231

20231231202312314400730730

Thomas Malley2024122Thomas Malley

2024123Olivier BrandicourtThomas MalleyOlivierBrandicourt20241232024319Olivier Brandicourt

20241232024321

20231231

202465

2024419

2024

183171712-1716

( www.hkexnews.hk )( www.beigene.com )20231231

2024328

Olivier BrandicourtMargaret Han DuganDonald W. GlazerMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders

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