百济神州：港股公告：2024中期报告

查股网 2024-09-27 百济神州(688235)公司公告

Cancer has no borders. Neither do we.

中期報告2024

?2024

2 4 7 26 76 77 78 80 81 83 120 124

?2024

Olivier Brandicourt

Margaret Han DuganDonald W. GlazerMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders

Anthony C. HooperOlivier Brandicourt

Corazon (Corsee) D. Sanders

Margaret Han DuganRanjeev Krishana

Donald W. GlazerMichael GollerAnthony C. HooperAlessandro Riva

Alessandro RivaMargaret Han DuganMichael GollerCorazon (Corsee) D. Sanders

Anthony C. HooperOlivier Brandicourt

Margaret Han DuganRanjeev KrishanaCorazon (Corsee) D. Sanders

* 2024122Thomas MalleyMalley

MalleyMalley

1. 2024123

2. 2024319

?2024

(FCG, HKFCG) Vistra Corporate Services (HK) Limited

Ernst & Young LLP

Mourant Governance Services (Cayman) Limited94 Solaris AvenueCamana BayGrand Cayman KY1-1108Cayman Islands

Mourant Ozannes

171712-1716

Mourant Governance Services (Cayman) Limited94 Solaris Avenue, Camana BayGrand Cayman KY1-1108Cayman Islands

06160

www.beigene.com

2024

???????????

?2024

???????????????

?2024

2024

GAAP

GAAPGAAPGAAPGAAP

GAAPGAAPGAAPGAAPGAAPGAAP

GAAP

GAAPGAAPGAAPGAAPGAAPGAAP

GAAP?

(BTKi)

?BTKi2024? 9.2956%? GAAPGAAP?

6.37107%

? BCL2sonrotoclaxBTKBGB-16673? 15ADC

?2024

2024723

1. 3,000

(CRO)75%

2. 1,100

???

(R/R)(CLL)(PFS)(ORR)BCL-2sonrotoclaxBTK(CDAC)BGB-16673

CDK4KRASPRMT5CDK2B7H3-ADCCEA-ADCB7H4-ADCMUC1×CD16AClaudin6×CD3CDACADCmRNA

?2024

???

306,000800ALPINE

?BTK2022(ASH)?

202312(FDA)

R/R CLL3ALPINEPFS?

2024630

2023116.7%

?sonrotoclaxBCL2BTK-CDACCLL

BPD-1

PD-1/PD-L1

CDK4KRASPRMT5CDK2B7H3-ADCCEAADCB7H4-ADCMUC1×CD16AClaudin6×CD3

4. 3,700500

2023CLL(SLL)

(BTKi)

BTKPD-1/PD-L1

2023

5. 2024630

26202463017

2024

?2024

20242023630

20242023%

1,668,064964,036704,02873.0% 12,75479,026(66,272)(83.9)%

1,680,8181,043,062637,75661.1%

263,067177,77985,28848.0%

1,417,751865,283552,46863.8% 915,104831,34883,75610.1% 871,156723,533147,62320.4% –375(375)(100.0)%

1,786,2601,555,256231,00414.9%

(368,509)(689,973)321,464(46.6)% 29,38531,086(1,701)(5.5)% (10,222)(45,515)35,293(77.5)%

(349,346)(704,402)355,056(50.4)%

22,20925,166(2,957)(11.7)%

(371,555)(729,568)358,013(49.1)%

?2024

202363010.4312024630

16.80861.1%

20242023630

20242023%1,668,064964,036704,02873.0% –20,380(20,380)(100.0)% –52,497(52,497)(100.0)% 12,7546,1496,605107.4%

12,75479,026(66,272)(83.9)%

1,680,8181,043,062637,75661.1%

20242023%?

1,125,914519,658606,256116.7%

303,687264,31439,37314.9%?

98,43544,16554,270122.9%?

33,49725,5247,97331.2%

30,04715,99514,05287.9%

28,20527,7644411.6%

21,36645,005(23,639)(52.5)%

26,91321,6115,30224.5%

1,668,064964,036704,02873.0%

2024

202463073.0%16.6819.640

2024630

11.259116.7%2024

8.3083.623

129.3%

?TN CLLCLLBTKi?

2024630

1.482

223.5%

2024630

3.0352.643

14.8%2024630

20246301.6208,570

20246301,280

20236307,900

20236301.77820246302.631??

202463014.0507.863

81.6%2024630

84.2%

?2024

20236308.3138,38010.1%20246

309.15120242023630

20242023%

247,633258,219(10,586)(4.1)% 46,528–46,528

35,96623,27412,69254.5%330,127281,49348,63417.3%584,977549,85535,1226.4%

915,104831,34883,75610.1%

787,949725,43162,5188.6%

1. 20246307,1003,600

3,5002.

GAAPGAAP2024630

3,5106.4%5.850

?2024

20242023%871,156723,533147,62320.4%

736,068614,761121,30719.7%1.

GAAPGAAP20236307.2351.47620.4%20246308.712

2024630

52.2%75.1%

20242024

20236303,1101705.5%20246302,940

20236304,55020246301,020

20236302,52020246302,22020242023630

?2024

GAAP

20242023GAAPGAAP263,067177,779

5,0294,360

2,3601,639

255,678171,780

GAAPGAAP915,104831,348

93,45179,97633,70425,941

787,949725,431

GAAPGAAP871,156723,533

125,95798,741

9,13110,031

736,068614,761

GAAPGAAP1,786,2601,555,256

219,408178,717

42,83535,972

–375

1,524,0171,340,192

GAAPGAAP(368,509)(689,973)

219,408178,717

47,86440,332

2,3602,014

(98,877)(468,910)

2024

2024630(1)11

(2)10014(3)1.266

202312313.58020246305.294

47.9%

202312314.16120246304.4336.5%

2023123113.242202463015.165

14.5%

20240630202312313.330

3.151

2024202363012313324,947302,310362,9678,205614,8434,551126545

333,022315,111

?2024

202463020231231

202420236301231167,960217,803133,412162,96970,64187,57248,46630,083173,263139,936

52,79655,368646,538693,731202312316.93720246306.465

6.8%2024630

202312318.860202463010.36917.0%

2024630

202463020231231

2024202363012312,617,9313,185,9841,036,928885,984

?2024

(BMS)BMS2023

GAAP

2024630

3.71620236307.296202463083

ADS201792024630

2024630(BeiGene, Ltd.)10(BeiGene, Ltd.)8.517

20211215

192.60391.68115,055,26034

2024630

20242023630

202420233,185,9843,875,037(404,160)(857,665)(320,863)308,863185,310146,212(28,340)(50,873)(568,053)(453,463)

2,617,9313,421,574

?2024

20246304.0423.716

2.6882.362

20236308.5777.296

3.2942.013

20246303.2092.6653,1804702,050

20236303.089

5.6752.4711,160

?2024

20246301.853910

3.2442,0401,4001.575

128.517

20236301.4621,580

1.618

3,5206,660

20246302,8305,090

(SEC)20235SEC

?2024

ADS

2024630

58,83511,08247,753120,36691,54428,8221,036,928851,657185,27160,84140,77220,069412,64780,312332,3358,1542,0256,12962,57662,576–

1,760,3471,139,968620,379

?2024

20246301.204

2,8809,150

128.5171.853

2024630

12.5

2024630

4.126

2024630820

20246306,260

?2024

20231231202463020246301.

20246307.3562024630100740

200520246302.2%202312312.8%

?2024

2024630

202463030.8%2023123125.0%

Hopewell2024630Hopewell677.12024

2024630

2024

10,0002023123110,000

2024630891.82023630

753.0

20246302,530202312311,420

1.714202312312.004

202463020231231

20246302023630

2024

2024630XV

(a)XV78

(b)352(c)

(1)28,513,658

(2)

2.07%

9,545,000

(3)

0.69%

102,188

(4)

0.01%

7,727,927

(5)

0.56%

28,334,115

(6)

2.06%

510,941

(7)

0.04%

481,533

(8)

0.04%

1,324,193

(9)

0.10%

15,647,052

(10)

1.14%

4,058,998

(11)

0.30%

1,127,542

(12)

0.08%

(13)

0.000004%

Olivier Brandicourt78,286

(14)

0.01%

Margaret Dugan164,307

(15)

0.01%

Donald W. Glazer3,159,151

(16)

0.23%

Michael Goller503,724

(17)

0.04%

Anthony C. Hooper234,377

(18)

0.02%

Ranjeev Krishana503,724

(19)

0.04%

Alessandro Riva164,307

(20)

0.01%

Corazon (Corsee) D. Sanders186,992

(21)

0.01%

486,642

(22)

0.04%

?2024

(1) 20246301,375,532,739

3,569,162

(2) (1)798,262(2)25,773,622

(3)960,846

(4)980,928

(3) Roth IRA PENSCO

(4) The John Oyler Legacy Trust

(5)

(6) Oyler Investment LLC

Oyler Investment LLC 99%

(7) The Oyler Family Legacy Trust

(8)(9)

(10) (1)5,343,251(2)10,078,622

(3)225,179

(11) Wang Investment LLCWang Investment LLC99%(12)(13)

(14) (1)BrandicourtBrandicourt61,945

(2)Brandicourt16,341

(15) (1)Dugan29,614(2)DuganDugan118,352(3) Dugan16,341

2024

(16) (1)Glazer2,672,509(2)GlazerGlazer

440,687(3) Glazer45,955

(17) (1)Goller46,696(2)GollerGoller440,687

(3) Goller16,341

(18) (1) Hooper7,800(2)HooperHooper

180,622(3) Hooper45,955

(19) (1) Krishana46,696(2)KrishanaKrishana440,687(3) Krishana16,341

(20) (1)Riva29,614(2)RivaRiva118,352

(3) Riva16,341

(21) (1)Sanders29,900(2)SandersSanders140,751(3) Sanders16,341

(22) (1)29,614(2)440,687

(3)16,3412024630

(a)XV7

(b)352(c)

?2024

2024630

XV23

(1)Amgen Inc.246,269,42617.90%Julian C. Baker

(2)

138,757,83110.09%Felix J. Baker

(2)

138,757,83110.09%Baker Bros. Advisors (GP) LLC

(2)

138,302,17110.05%Baker Bros. Advisors LP

(2)

138,302,17110.05%HHLR Advisors, Ltd.

(3)

133,587,6559.71%HHLR Fund, L.P.

(3)

129,433,0599.41%Baker Brothers Life Sciences Capital, L.P.

(2)

126,893,3119.23%The Capital Group Companies, Inc.(4)

110,035,4538.00%JPMorgan Chase & Co.

(5)

7,960,0750.58%6,597,273 (S)0.48%(S)

2,821,5310.21%7150.0001%7,3190.0005%100,691,4407.32%

(S)

(1) 20246301,375,532,739

3,569,162

?2024

(2) Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLC

Baker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.

BBAMichael GollerRanjeev Krishana

BBABaker Brothers Life Sciences Capital, L.P.Baker Bros. Advisors (GP) LLCJulian C. BakerFelix J.Baker2023111420231114125,986,847Baker Brothers Life Sciences, L.P.Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBBA667, L.P.11,408,860BakerBrothers Life Sciences, L.P.125,986,847723,996BBABaker Brothers Life Sciences Capital, L.P.

Baker Brothers Life Sciences, L.P.125,986,847723,996BBAJulian C. BakerFelix J. Baker270,868FBB3 LLC144,517

(3) (i) 133,587,655HHLR Fund, L.P. YHG Investment, L.P.(ii) 13,447,603HillhouseBGN Holdings LimitedHHLR Adrisors, Ltd.YHG Investment, L.P.HHLR Fund,L.P.Hillhouse Capital Management, Ltd.Hillhouse Fund II, L.P.Hillhouse Fund II, L.P.Hillhouse BGN Holdings LimitedHHLR Adrisors, Ltd.

HHLR Fund, L.P.YHG Investment, L.P. 133,587,655Hillhouse CapitalManagement, Ltd.Hillhouse BGN Holdings Limited13,447,603Hillhouse Fund II, L.P.Hillhouse BGN Holdings Limited13,447,603

(4) (i) 11,057,735Capital International, Inc.(ii) 1,030,864Capital International Limited

(iii) 2,543,315Capital International Sarl(iv) 92,623,415Capital Research andManagement Company(v) 220,736Capital Group Investment Management Private Limited(vi) 2,559,388Capital Group Private Client Services, Inc.Capital Group International, Inc.Capital Research and Management CompanyCapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.Capital Group International,Inc.Capital Bank and Trust CompanyThe Capital Group Companies, Inc.Capital Research and Management CompanyCapital Group International, Inc.CapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.17,412,038Capital Research and Management CompanyThe Capital Group Companies Inc.The Capital Group Companies Inc.Capital Research and Management Company

110,035,453

(5) JPMorgan Chase & Co. 2024614

JPMorgan Chase & Co. 111,481,0806,597,273100,691,4401,653,836100,377

2024630

XV23

?2024

201120162018201120162024652018202465

20231231

202465202420162018

201620162018201817201620182024426

202465(i)201692,820,000

2016(ii)35,169,0942016(iii)20185,070,0002018

(iv)919,6782018

2024652024630202463088,049,174

20,409,69720162018201620182016

20182024652024630

202463020,409,697

2024652024630

53,196,494

3.87%202431202483120182024831

?2024

1. 2011

20114152015417201120162220162011

2011

201143,560,4322016222016

201120241120111,427,6862011

626,47020246302024916801,184751,83020249160.1%2011

20112011

?2024

2011

0.011.85

2011

20112016222016201120112018730

?2024

2011

202463020112402011

2011520201613120241120246302011

2024

2015629

(1)

100.50500,000500,000Thomas Malley*2016125

(2)

(6)

1.85552,752552,747

(4)

2015629

(3)

100.5011112011520

2016 131

(3)

100.01

1.85

327,62169,940

(5)

32257,6492011520

2016 131

(3)

100.01

1.85

47,3023,783

(7)

43,519

1,427,686626,470–32801,184

?2024

* Thomas Malley2024122

(1) 20%80%20%48(2)

(3) 20%/25%80%/75%20%/25%48/36

(4) 1312.3913.08

(5) 1310.9113.40

0.301.85

(6) Thomas Malley2024122Thomas Malley20241232024122

(7) 1310.97

0.01

?2024

2. 20162024652016

201616

2016

(i)(ii)(iii)(iv)(v)(vi)(vii)

?2024

202411201637,575,472202411202464

4,732,637201620246520162016

202465202463048,463,85720162024630202491682,059,49682,355,85720,409,697

20,409,6972016

2024112016165,493,25520162024112024644,282,8892024652016

2016

2016202465202463014,882,79020246302024916239,147,604236,409,361202491617.14%2016

20162016121%

?2024

(1)(2)(3)(4)(5)(6)

(7) 12

2016(x)

(y)

2016

2024

2016

2016203041320165.520162016

2024630201620161,176201620162016282024628

201620160.5

28.81

20241161,516,7602016202463067,378,46220162016

(1)(2)

2024

2016 1116

(3)

102.792.842,047,500––––2,047,5002017 927

(3)

106.737.70935,000––––935,0002018 430

(3)

1013.3713.04996,810––––996,8102018 626

(3)

1012.7012.341,310,088––––1,310,0882019 65

(3)

109.259.232,193,282––––2,193,2822020 617

(3)

1013.3313.421,821,976––––1,821,9762021 616

(3)

1025.5426.53906,906––––906,9062022 622

(3)

1011.7411.981,887,678––––1,887,6782023 615

(3)

1016.0116.411,349,907––––1,349,9072024 65

(3)

1011.9312.23–923,975–––923,975

?2024

(1)(2)

2024

2016 1116(3)

102.792.841,613,430––––1,613,4302017 927(3)

106.737.70750,000––––750,0002018 626(3)

1012.7012.34655,044––––655,0442019 65(3)

109.259.23747,708––––747,7082020 617(3)

1013.3313.42560,599––––560,5992021 616(3)

1025.5426.53241,839––––241,8392022 622(3)

1011.7411.98471,913––––471,9132023 615

1016.0116.41327,249––––327,2492024 65

(3)

1011.9312.23–410,657–––410,657Anthony C. Hooper

2020 33

(5)

1012.6212.2221,970––––21,9702020 617

(5)

1013.3313.4245,383––––45,3832021 616

(5)

1025.5426.5317,498––––17,4982022 622

(5)

1011.7411.9834,645––––34,6452023 615

(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151Olivier Brandicourt

2024 229

(5)

1013.7312.74–27,794–––27,7942024 65

(5)

1011.9312.23–34,151–––34,151

?2024

(1)(2)

2024

Margaret Han Dugan

2022 228(5)

1016.4716.2222,581––––22,5812022 622(5)

1011.7411.9834,645––––34,6452023 615(5)

1016.0116.4126,975––––26,9752024 65(5)

1011.9312.23–34,151–––34,151Donald W. Glazer

2017 419

(4)

102.842.83199,992––––199,9922018 66(5)

1015.7316.1517,442––––17,4422019 65

(5)

109.259.2364,610––––64,6102020 617

(5)

1013.3313.4245,383––––45,3832021 616

(5)

1025.5425.6317,498––––17,4982022 622

(5)

1011.7411.9834,645––––34,6452023 615

(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151Michael Goller

2017 419

(4)

102.842.83199,992––––199,9922018 66

(5)

1015.7316.1517,442––––17,4422019 65

(5)

109.259.2364,610––––64,6102020 617

(5)

1013.3313.4245,383––––45,3832021 616(5)

1025.5425.6317,498––––17,4982022 622

(5)

1011.7411.9834,645––––34,6452023 615

(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151

?2024

(1)(2)

2024

Ranjeev Krishana

2017 419(4)

102.842.83199,992––––199,9922018 66(5)

1015.7316.1517,442––––17,4422019 65

(5)

109.259.2364,610––––64,6102020 617

(5)

1013.3313.4245,383––––45,3832021 616

(5)

1025.5425.6317,498––––17,4982022 622

(5)

1011.7411.9834,645––––34,6452023 615

(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151Thomas Malley

2017 62

(5)

(10)

2.9413.083.15169,988–169,988–––2018 66

(5)

(10)

15.7316.1517,442––––17,4422019 65

(5)

(10)

9.2513.099.2364,610–64,610–––2020 617

(5)

(10)

13.3313.4245,383––––45,3832021 616(5)

(10)

25.5425.6317,498––––17,4982022 622(5)

(10)

11.7411.9834,645––––34,6452023 615

(5)

(10)

16.0116.4126,975––––26,975

?2024

(1)(2)

2024

Corazon D. Sanders

2020 824

(5)

1018.5018.2627,482––––27,4822021 616(5)

1025.5425.6317,498––––17,4982022 622(5)

1011.7411.9834,645––––34,6452023 615(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151Alessandro Riva

2022 228

(5)

1016.4716.2222,581––––22,5812022 622

(5)

1011.7411.9834,645––––34,6452023 615

(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,1512017 419

(4)

102.842.83199,992––––199,9922018 66

(5)

1015.7316.1517,442––––17,4422019 65

(5)

109.259.2364,610––––64,6102020 617

(5)

1013.3313.4245,383––––45,3832021 616

(5)

1025.5425.6317,498––––17,4982022 622

(5)

1011.7411.9834,645––––34,6452023 615(5)

1016.0116.4126,975––––26,9752024 65

(5)

1011.9312.23–34,151–––34,151

?2024

(1)(2)

2024

2018 430

(6)

1013.3713.04766,599––––766,5992019 65(3)

109.259.23797,550––––797,5502020 617(3)

1013.4213.33756,821––––756,8212021 616

(3)

1025.5425.63483,678––––483,6782022 622

(3)

1011.7411.981,061,814––––1,061,8142023 615

(3)

1016.0116.41760,851––––760,8512024 65

(3)

1011.9312.23–477,386–––477,386**2020

(3)

(11)

14.5514.66104,754––––104,7542021 616

(3)

(11)

25.5426.53177,853––––177,8532022 622

(3)

(11)

11.7411.98589,888––––589,8882023 615

(3)

(11)

16.0116.41409,058––––409,0582024 65

(3)

(11)

11.9312.23–256,659–––256,659

?2024

(1)(2)

2024

2018 626(3)

1012.7012.34364,208––––364,2082019 65(3)

109.259.23558,285––––558,2852020 617(3)

1013.3313.42525,564––––525,5642021 616

(3)

1025.5426.53332,527––––332,5272022 622(3)

1011.7411.98707,876––––707,8762023 615(3)

1016.0116.41507,234––––507,2342024 65(3)

1011.9312.23–318,253–––318,253Chan Lee

2022 85

(3)

102.262.27188,929––––188,9292023 615

(3)

1016.0116.41248,950––––248,9502024 65

(3)

1011.9312.23–184,795–––184,7952016 713

(3)

102.272.29200,000–––200,0002024 229

(12)

1013.7312.74–16,380––16,380

?2024

(1)(2)

2024

2016 713(3)

102.2713.692.292,754,293–130,000–72,624,2862016 722(3)

102.1313.082.1068,827–12,974––55,8532016 722(6)

102.1312.552.10732,232–20,475–14711,7432016 729(3)

102.112.023––3––2016 1012(3)

102.482.426–––62016 1017

(3)

102.4211.652.5556,212–10,725–45,4872016 1130

(3)

102.432.441,274–––1,2742016 129

(3)

102.072.0934,099–––34,0992017 13

(3)

102.342.397,800–––7,8002017 117

(6)

102.5113.002.5335,763–650––35,1132017 21

(3)

102.682.77144,989–––144,9892017 26

(3)

102.762.7632,201–––32,2012017 213

(3)

102.7712.392.779,243–7,800–1,4432017 313

(3)

103.083.02116,701–––116,7012017 320

(3)

103.0412.053.0469,368–19,500–49,8682017 331

(6)

102.8111.022.8228,704–858–27,846

?2024

(1)(2)

2024

2017 52

(6)

103.1313.983.12100,854–403–100,4512017 53

(3)

103.123.1211,999–––11,9992017 61(6)

102.8312.792.94147,914–75,907–72,0072017 612

(3)

102.9911.853.0012,727–12,727––2017 614(3)

103.0413.453.05407,160–5,941–401,2192017 615

(6)

103.0511.743.042,747,446–157,976––2,589,4702017 627

(3)

103.5013.633.492,132,624–65,208–2,067,4162017 629

(3)

103.503.4533,657–––33,6572017 710

(3)

105.4013.005.451,300–1,300––2017 717

(6)

105.6712.664.19234,130–13,741–220,3892017 731

(3)

105.5813.085.4260,996–60,996––2017 731

(6)

105.585.42285,519–––285,5192017 81

(3)

105.425.5839,000–––39,0002017 83

(3)

105.455.5119,994–––19,9942017 87

(3)

105.565.9539,000–––39,0002017 828

(3)

105.295.2824,167–––24,167

?2024

(1)(2)

2024

2017 831

(6)

105.3012.425.30168,168–15,743–152,4252017 95

(3)

105.785.6835,009–––35,0092017 918

(3)

106.226.3722,269–––22,2692017 925(3)

106.5512.616.56121,992–70,499–51,4932017 929

(3)

107.497.9637,492–––37,4922017 111

(3)

107.1012.166.84199,056–108,862–90,1942017 1130

(3)

106.386.1510,764–––10,7642018 15

(3)

107.727.5819,071–––19,0712018 131

(3)

109.5210.4480,017–––80,0172018 430

(3)

1013.3713.046,149–––6,1492018 66

(5)

1015.7316.1517,442–––17,4422018 626

(3)

1012.7013.1112.34641,433–75,660–565,7732018 629

(3)

1011.9011.8312,103–––12,1032018 831

(7)

1013.6713.666,708–––6,7082018 928

(3)

1013.2813.2565,433–––65,4332018 928

(8)

1013.2813.2539,260–––39,2602018 1130(3)

1011.0711.7911,028–––11,0282018 1231

(3)

1010.5310.79107,016–––107,0162018 1231

(8)

1010.5310.7912,194–––12,194

?2024

(1)(2)

2024

2019 125

(3)

109.6210.4438,649–––38,6492019 35(3)

1011.6811.9311.5178,494–55,289–23,2052019 510

(3)

109.3310.3244,213–––44,2132019 65(3)

109.2512.789.231,865,240–195,169–1,670,072019 65

(5)

109.259.23129,220–––129,2202019 830(3)

1011.1411.0679,300–––79,3002020 331(3)

109.659.67294,775–––294,7752020 617

(3)

1013.3313.6113.421,182,181–12,0253,09429,3671,137,6952020 617

(5)

1013.3313.4290,766–––90,7662020 630

(3)

1014.5514.66212,771–––196,40416,3672020 87

(3)

1017.2416.9940,248–––40,2482020 930

(3)

1021.6522.038,021–––8,0212020 116

(3)

1023.0823.07162,994––––162,9942020 1130

(3)

1021.9920.9915,756––3,04212,714–2021 122

(3)

1027.4628.8155,263––1,05354,2102021 226

(3)

1025.3625.816,331––1,6384,693–2021 331

(3)

1025.6126.78148,824–––148,8242021 57

(3)

1024.1524.7884,240–––84,2402021 528

(3)

1027.0027.58121,485–––121,485

?2024

(1)(2)

2024

2021 616

(3)

1025.5426.531,608,737––9,490135,5121,463,7352021 616

(5)

1025.5426.5317,498––––17,4982021 630(3)

1027.4827.2848,113––5,0053,61439,4942021 86(3)

1025.8425.6168,341––––68,3412021 831(3)

1023.2223.72153,322––5,746147,5762021 930(3)

1027.8128.7355,458––––55,4582021 115

(3)

1028.3828.0823,231––––23,2312021 1130

(3)

1026.4026.8564,649––5,6555,92853,0662021 1231

(3)

1021.0320.8426,637––4,8365,21316,5882022 127

(3)

1017.2718.61371,059–––371,0592022 228

(3)

1016.4718.8116.22151,580––––151,5802022 331

(3)

1015.8515.46135,694–––135,6942022 56

(3)

1012.2714.3112.5063,349–––63,3492022 531

(3)

1010.3010.56123,604–––123,6042022 622

(3)

1011.7412.5811.985,102,089–118,040298,7664,685,2832022 622

(9)

1011.7411.9811,804–––11,8042022 630

(3)

1012.4812.8174,217––6,13668,0812022 831(3)

1012.7313.3222,009–––22,0092022 930(3)

1010.4810.5863,024–––63,024

?2024

(1)(2)

2024

2022 1110(3)

1013.5614.5246,176–––46,1762022 1130

(3)

1013.8414.7417,745–––17,7452022 1230(3)

1017.2217.267,592–––7,5922023 125(3)

1020.5220.6429,471––4,5501,50823,4132023 228(3)

1016.6217.2861,724–––61,7242023 331

(3)

1016.6716.9951,844––7,00744,8372023 55

(3)

1020.0520.0618,395–––18,3952023 531

(3)

1017.5617.9819,188–––19,1882023 615

(3)

1016.0116.415,183,529––243,6854,939,8442023 630

(3)

1013.7413.8230,277–––30,2772023 83

(3)

1014.6016.0866,729–––66,7292023 831

(3)

1016.2515.9754,314––16,14638,1682023 929

(3)

1014.1714.51192,686–––192,6862023 1113

(3)

1015.3215.3024,297–––24,2972023 1130

(3)

1014.0914.3832,968––22,38610,5822023 1229

(3)

1013.8113.8750,271–––50,2712024 124

(3)

1012.4812.40–49,673––49,6732024 229

(3)

1013.7312.74–12,012––12,0122024 328

(3)

1011.9312.03–74,464––74,464

2024

(1)(2)

2024

2024510

(3)

1012.9712.59–155,792––155,7922024531

(3)

1011.8711.81–145,340––145,340202465

(3)

1011.9312.23–5,011,318–16,7574,994,5612024628

(3)

1011.2011.67–22,880––22,880

61,516,7608,394,7371,483,066654,995394,97467,378,462

* Thomas Malley2024122** 2024719

(1) 13

(2) 13

(3) 25%

75%25%36(4)(5)

Thomas Malley2024122Thomas Malley20241232023615Thomas Malley

20241232024630

(6) 20%80%20%48

?2024

(7) 48(8)

(9) 50%50%50%12

(10) Thomas Malley2024122Thomas Malley

Thomas Malley

(11) 2024717

(12)

2024

2016

(3)

923,975202465(1)12.23–11.935,999,924410,657202465(1)12.23–11.932,666,642Anthony C. Hooper34,151202465(2)12.23–11.93199,995Olivier Brandicourt27,7942024229(2)12.74–13.73158,862

34,151202465(2)12.23–11.93199,995Margaret Han Dugan34,151202465(2)12.23–11.93199,995Donald W. Glazer34,151202465(2)12.23–11.93199,995Michael Goller34,151202465(2)12.23–11.93199,995Ranjeev Krishana34,151202465(2)12.23–11.93199,995Corazon D. Sanders34,151202465(2)12.23–11.93199,995Alessandro Riva34,151202465(2)12.23–11.93199,995

34,151202465(2)12.23–11.93199,995477,386202465(1)12.23–11.933,099,954*256,659202465(1)12.23–11.931,666,641

318,253202465(1)12.23–11.932,066,608Chan Lee184,795202465(1)12.23–11.931,199,985

5,471,4792024124

2024 628

(1)11.67-

12.74

–11.20-

13.73

35,489,28016,3802024229(4)12.74–13.7399,9528,378,35754,247,803

?2024

* 2024719

(1) 25%

75%25%36

(2)

10Thomas Malley2024122Thomas Malley20241232023615Thomas Malley20241232024630

Thomas Malley(3)

(4) 100%

2016201620246302016201616,704

3120162016

20179262024628

?2024

20241166,401,02320162016

202463087,422,2442,287,40220162016

2024

2024(1)

2021616(6)25.5473,138–36,556–36,58212.512022622(6)11.74250,510–83,499–167,01112.012023615(6)16.01355,641–88,907–266,73412.51202465(6)11.93–490,464––490,464–202465(9)11.93–490,464

(10)

––490,464–2021616(6)25.5419,500–9,750–9,75012.512022622(6)11.7462,634–20,865–41,76912.012023615(6)16.0186,216–21,554–64,66212.51202465(6)11.93–108,992––108,992–Anthony C. Hooper2022622(7)11.7416,692–––16,692–

2023615(7)16.0112,922–––12,922–202465(7)11.93–16,341––16,341–Olivier Brandicourt202465(7)11.93–16,341––16,341–Margaret Han Dugan2023615(7)16.0112,922–12,922––11.93

202465(7)11.93–16,341––16,341–Donald W. Glazer2022622(7)11.7416,692–––16,692–

2023615(7)16.0112,922–––12,922–

202465(7)11.93–16,341––16,341–

2024

(1)

Michael Goller2023615(7)16.0112,922–12,922––11.93

202465(7)11.93–16,341––16,341–Ranjeev Krishana2023615(7)16.0112,922–12,922––11.93

202465(7)11.93–16,341––16,341–Thomas Malley*2023615(7)16.0112,922––12,922––Corazon D. Sanders2023615(7)16.0112,922–12,922–––

202465(7)11.93–16,341––16,341–Alessandro Riva2023615(7)16.0112,922–12,922–––

202465(7)11.93–16,341––16,341–

2023615(7)16.0112,922–12,922–––

202465(7)11.93–16,341––16,341–

2020617(6)13.3333,566–33,566––12.01

2021616(6)25.5439,000–19,500–19,50012.01

2022622(6)11.74140,907–46,969–93,93812.51

2023615(6)16.01200,447–50,102–150,34512.01

202465(6)11.93–253,409––253,409–

202465(11)11.93–253,409

(10)

–– 253,409–**2020630(6)14.5513,819–13,819–––

2021616(6)25.5414,352–7,163–7,18912.512022228(6)16.4746,319–15,431–30,88813.822022622(6)11.7478,286–26,091–52,19512.012023615(6)16.01107,770–26,936–80,83412.51202465(6)11.93–136,240––136,240–202465(11)11.93–136,240

(10)

––136,240–

?2024

2024

(1)

2020617(6)13.3323,309–23,309––12.512021616(6)25.5426,819–13,403–13,41612.512022622(6)11.7493,951–31,304–62,64712.012023615(6)16.01133,627–33,397–100,23012.51202465(6)11.93–168,935––168,935–202465(11)11.93–168,935

(10)

––168,935–Chan Lee

2022729(6)13.4587,009–––87,009–2023615(6)16.0165,585–16,393–49,19212.51202465(6)11.93–98,085––98,085–202465(11)11.93–98,085

(10)

––98,085–2018131 2021 1231

(6)18.558,302,047–4,079,491495,6643,726,892(2)202211 2022 1231

(6)12.2823,899,564–6,464,1721,276,41816,158,974(3)202311 2023 1229

(6)15.6232,088,680–6,439,2381,748,40923,901,033(4)202411 2024 630

(6)12.21–41,103,3223,666277,10840,822,548(5)202465(11)11.93–1,140,269

(10)

––1,140,269–

?2024

2024

(1)202311 2023 1231

(8)13.818,645–––8,645202411 2024 630

(12)13.73–7,839––7,839

66,401,02344,801,75717,682,6133,810,52189,709,646

* Thomas Malley2024122** 2024719

(1) 13

(2) 1310.9713.73

(3) 1310.9713.73

(4) 1310.97

(5) 1310.97

(6) 25%

2024

(7)

Thomas Malley2024122Thomas Malley(8)(9)

(10) 100%

0200%(11)(12)

(3)490,464202465(1)–11.935,999,884490,464202465(5)(6)11.935,999,884108,992202465(1)–11.931,333,308Anthony C. Hooper16,341202465(2)–11.93199,901Olivier Brandicourt16,341202465(2)–11.93199,901Margaret Han Dugan16,341202465(2)–11.93199,901Donald W. Glazer16,341202465(2)–11.93199,901Michael Goller16,341202465(2)–11.93199,901Ranjeev Krishana16,341202465(2)–11.93199,901Corazon D. Sanders16,341202465(2)–11.93199,901Alessandro Riva16,341202465(2)–11.93199,901

16,341202465(2)–11.93199,901

?2024

(3)253,409202465(1)–11.933,099,972253,409202465(7)(6)11.933,099,972*136,240202465(1)–11.931,666,634

136,240202465(7)(6)11.931,666,634Chan Lee98,085202465(1)–11.931,199,881

98,085202465(7)(6)11.931,199,881

168,935202465(1)–11.932,066,595

168,935202465(7)(6)11.932,066,595

41,103,3222024124

2024628

(1)–15.62502,066,0351,140,269202465(7)(6)11.9313,948,998

7,8392024229(4)–13.7399,88744,801,757519,331,305

* 2024719

(1) 25%

(2)

Thomas Malley2024122Thomas Malley(3)(4)

?2024

(5)

(6) 0200%(7)

3. 20182024652018

2018201815%

20182018

201820185%

2018

1%10%25,000

?2024

3191

2018

85%

2018

17.03(13)

?2024

20241120181,941,075202411

2023912024112024641,021,397201820246520182018

20246520246302018202463020249165,989,6784,953,68220182024630

2024630202431

20241120181,941,0752024112024642023911,021,397201820246520182018202465202463020182024

63020249165,989,6784,953,6822024916

0.36%2018

2018

20182024652028127

20184

20182018

2023913,0392018

?2024

20182018

2023

202391

(1)(2)

202391610.8310,623.308,307.35

10.83

202391610.8311,808,23511,054,404

10.83

1,020,630

11,062,712

1. 20239115.97125.26

16,414,635128,751,1482023912018

?2024

2. 202391

2018202422910.831,021,3972024229

12.7499.7113,014,955101,865,320

3. 20239111,816,543

1,021,397

4. 2018

?2024

C1C.2.1

Ranjeev Krishana

?2024

3.21D.3.3D.3.7

Anthony C.HooperOlivier BrandicourtCorazon (Corsee) D. SandersAnthony C. Hooper

3.10(2)3.21Thomas Malley2024122Thomas Malley2024123Olivier BrandicourtMalleyOlivier Brandicourt20241

3.25E.1.2

MargaretHan DuganRanjeev KrishanaMargaret Han Dugan

3.27A

B.3.1

Donald W. GlazerMichael GollerAnthony C. HooperAlessandro RivaDonald W. Glazer

?2024

B.8

202411

2024630

?2024

13.51B(1)

Thomas Malley2024122Olivier Brandicourt2024123

2024319

202012

174.8515,895,001206,635,013

20.5%2,779,241,000(a)201910303036%(b)1.007.8420191031

?2024

201911292024630

20231231

2024

(%)(a)

2,779,241100%2,229,6322,294,982484,259(a) 12.5

20191129

202620191112019129202013

2021121520216162021

192.60

234.89391.68115,055,260

3,392,616,000(i)(ii)(iii)(iv)(v)20231110

?2024

202011162021129202142020215142021612021621202162820216302021792021728202110152021111620211123202111242021112920211130202112220211262021127202112132021122120211228202242920226272022830202292820234252023829202311132021430

202463016057

2024630

20231231

2024

13,245,9407,169,4708,651,1674,594,773

467,700434,188462,4145,286150,000153,451153,451(3,451)*136,360110,240137,268(908)*6,000,0004,832,2815,578,830421,1701,630,155978,000978,000652,15521,630,15513,677,63015,961,1305,669,025

2024630

?2024

2024202363020242023630

30003000(i) 2323

20246302024

(ii) 232024630

(iii) 23

?2024

3000

(i) 23(ii) 232024630

(iii) 23

Anthony C. HooperOlivierBrandicourtCorazon (Corsee) D. SandersAnthony C. Hooper

3.10(2)3.21Thomas Malley2024122Malley2024123OlivierBrandicourtMalleyOlivier Brandicourt2024123

2024630

?2024

2024630

13.2013.2113.22

2024827

?2024

20242023

131,668,064964,036 312,75479,026 1,680,8181,043,062

263,067177,779

1,417,751865,283 915,104831,348 871,156723,533 –375

1,786,2601,555,256

(368,509)(689,973) 29,38531,086 (10,222)(45,515)

(349,346)(704,402)922,20925,166

(371,555)(729,568)15(0.27)(0.54)

1,358,315,1451,357,211,308

ADS15(3.56)(6.99)

ADS104,485,780104,400,870

?2024

20242023(371,555)(729,568) 17(41,399)(73,172) 406– 17(35)6,902

(412,583)(795,838)

2024

202420236301231

2,592,6553,171,800 5529,449358,027 6443,260416,122 10273,658257,465

3,839,0224,203,414

71,516,4911,324,154 103,63395,207 853,71557,138 10199,318125,362

1,873,1571,601,8615,712,1795,805,275

11333,022315,111 10646,538693,731 95,27822,951 17,65821,950 384,61568,004 12851,657688,366

1,938,7681,810,113

?2024

202420236301231

12185,271197,618 35,39822,251 915,94216,494 3119,012170,662 1051,53350,810

407,156457,835

2,345,9242,267,948

0.0001 9,500,000,0002024630 20231231 1,379,101,9011,359,513,224137135 11,840,19711,598,688 17(140,474)(99,446) (8,333,605)(7,962,050)

3,366,2553,537,327

5,712,1795,805,275

2024

202312311,359,513,22413511,598,688(99,446)(7,962,050)3,537,327

(1,216,016)––––– 20,804,693220,153––20,155

––219,304––219,304––2,052––2,052–––(41,028)–(41,028)––––(371,555)(371,555)20246301,379,101,90113711,840,197(140,474)(8,333,605)3,366,255

202212311,356,140,18013511,540,979(77,417)(7,080,342)4,383,355

121,342––––– 19,989,814232,347––32,349

––178,693––178,693–––(66,270)–(66,270)––––(729,568)(729,568)

20236301,376,251,33613711,752,019(143,687)(7,809,910)3,798,559

2024

20242023

(371,555)(729,568) 50,22442,346 16219,304178,693 (3,735)– 3(35,039)(22,669) 5,4132,930 (173,896)(131,923) (35,949)(53,598) (32,233)(30,627) 2,192(32,678) (28,256)(8,082) 216(72,577) (846)88

(404,160)(857,665)

(266,528)(247,055) (4,674)– 2,655567,500 (31,800)– (20,516)(11,582)

(320,863)308,863

?2024

20242023

129,05315,771 12(14,020)– 12324,412161,846 12(157,490)(66,574) 20,35535,169 3,000–

185,310146,212

(28,340)(50,873)(568,053)(453,463)3,185,9843,875,037

2,617,9313,421,574

2,592,6553,410,368 23,1559,693 2,1211,513 45,63632,529 24,14810,015 115,56495,404 40,798–

?2024

?(BTK)

PD-1

PARP1PARP2??

CRO3,000CRO

?2024

2024630

2,722,787,023

100%

15,424,108,600

100%

1,434,344,311

100%

620,000,000

100%

4,273,218,389

100%BeiGene Switzerland GmbH20,000100%BeiGene USA, Inc.1100%BeiGene Hopewell Urban Renewal, LLC

613,943,128100%BeiGene AUS Pty Ltd56,947,230100%*

2024

202463020242023630

2024202363020242023630

()10-QS-X10

2023123110-K

2024630

?2024

2023112023-07280

2023121520241215

2023122023-09740

(1)(2)5%(3)

20241215

20231231

2024630

?2024

202463020231231

2024630123

897,906–– ––4,968

1,440115– ––4,773

899,3461159,741

?2024

20231231123

1,052,149–– 42,852–– 2,600–– ––4,668

3,046542– ––4,215

1,100,6475428,883

Leap Therapeutics, Inc.LeapLeap

1Leap

202463020231231

?2024

20231231

20246302023630

20242023630

20242023–20,380–52,49712,7546,14912,75479,026

?2024

20239

20232024630

20246302023630

20242023–16,796

(1)

2,1135,0132,11321,809

(1)

?2024

20237

20246302023

20242023–3,583–52,4978,5012,6368,50158,716

20242023630

20231231

?2024

20242023630

2024202335,96623,27435,03922,66971,00545,943

2024630

412,647202463020231231

20242023630123184,61568,004119,012170,662203,627238,666

?2024

20242023630

2024202318,1591,184(1,144)1,311(39,253)(29,388)(22,238)(26,893)

2024630109,879,000202363039,277,00020246302023123166,824,00055,474,000

2024

20242023630

20242023

27–46,500–46,527–

202463020231231

20242023630123123,15511,473

2,1212,711

25,27614,184

2024630856,722,000

?2024

202420236301231(1)

Leap1,4403,046 Leap115542 Pi Health, Inc.

(2)

40,798– 54,86555,860

37,78025,981134,99885,429

(1) Leap

(2) 2024Pi Health38,063,000

Pi Health, Inc.40,798,0001,000,00020246303,735,000Pi Health

20242023630

20242023(2,033)(636)

(797)1,081

(4,873)(2,624)

?2024

202420236301231530,300360,053

(851)(2,026)

529,449358,027

30120

2024202363012316528,516356,2436129331,784

529,449358,027

20242023630

202420232,026211(1,214)234

(1)(43)

40(16)851386

?2024

202420236301231143,655148,772

59,49939,098240,106228,252443,260416,122

202420236301231

65,48565,485304,854231,656227,146186,856216,673205,349

60,38260,124

67,64983,281942,189832,751(289,114)(249,212)863,416740,6151,516,4911,324,154

2024630677,126,0002024

?2024

7.2024373,373,000

28,699,00044,674,0002024522,637,0002024630

2024630202463047,864,000202363040,332,000

202463020231231

63,098(10,054)53,04464,274(7,807)56,467 8,987(8,316)6718,987(8,316)671

72,085(18,370)53,71573,261(16,123)57,138

2024

202420232,3601,639–3752,3602,014

2024630

123120242,348672,41520254,696674,76320264,696674,76320274,696674,76320284,696674,763202931,91233632,248

53,04467153,715

202463022,209,000202363025,166,00020242023630

?2024

2024

202463015,804,00012

20246301,540,000

10.

20242023630123168,23460,47632,98642,06632,19337,32058,77637,85923,15511,47310,1588,87248,15659,399273,658257,465

2024

10.

202420236301231

(1)

34,3354,144

12,48718,1222,6022,5468,0028,1952,1212,711

139,77189,644199,318125,362

(1) 20246307

202420236301231167,960217,803133,412162,969

70,64187,572

48,46630,083173,263139,936

52,79655,368646,538693,731

2024

10.

20242023630123132,02134,20414,63914,9951,1011,1273,77248451,53350,810

11.

2024202363012313324,947302,310362,9678,205614,8434,551126545

333,022315,111

2024

12.

202463020231231

202463020231231580,0009202744(1)15,136110,00014,089100,000350,00092029120(2)8,64962,8578,85662,857378,00092029118(3)6,84849,7655,63640,000380,0001(4)380,0002,761,628300,0002,129,321150,0001202412197.3%150,0001,090,116150,0001,064,660

675,0003642025327(5)92,880675,000––400,00012025653.0%55,040400,00056,356400,000340,0001202555(6)46,784340,00047,903340,000200,00012024529–––28,177200,000700,0001(7)2.9%96,320700,00049,312350,000

(8)––28,037199,000

851,6576,189,366688,3664,885,838580,0009202744(1)49,536360,00059,174420,000350,00092029120(2)32,434235,71437,638267,143378,00092029118(3)37,253270,73542,337300,500480,000102032728(9)66,048480,00058,469415,000

185,2711,346,449197,6181,402,643

(1) 2024630

4.2%20246306,886,00050,000,000

(2) 20246303.7%

20246304,362,00031,429,000

2024

12.

(3) 2024630

3.9%2024630

2,772,00020,000,000

(4) (SOFR)20246307.2%

300,000,0002024122580,000,0002025127

(5) 2024630

2.6%

(6) 20246305.7%

(7) 48,160,000350,000,000202411212025319

(8) 20231231

875,000,000202463027,476,000199,000,000

(9) 20227

480,000,00020246309,053,00065,000,00020246303.9%

20246

202463025,637,00017,521,00020236309,465,000772,000

?2024

13.

??????

20242023630

202420232,111,6191,176,933(443,555)(212,897)1,668,064964,036

20242023630

20242023?

1,125,914519,658?

303,687264,314?

98,43544,165?

33,49725,524?

30,04715,995

28,20527,764

21,36645,005

26,91321,6111,668,064964,036

?2024

13.

20242023630

20242023139,93641,817443,555212,897(410,228)(169,123)173,26385,591

14.

20242023263,067177,779

47,97040,332915,104831,34813,23513,42982,3602,014

633,187542,029 219,408178,717 39,22032,302

891,815753,048

(3,735)–

13,52368,9115(1,214)234

2,4843,030(38,145)(40,584) 20242023630384,854,000344,713,000

?2024

15.

20242023

(371,555)(729,568) 1,358,315,1451,357,211,308

(0.27)(0.54)

20242023630

16.

201620161201620162016265,029,595

201620112011

20162011201812201638,553,15920206

201657,200,00020304132016

?2024

16.2016

20162016

201666,300,00020226222024620162016

92,820,0002024630201120165,166,848202463020168,394,73742,514,3552,287,40220246302016

67,378,46287,422,2442,287,4022024630201682,059,49620182018620183,500,00020188

2018123,855,315

7,355,3152019620216

202191202462018175,070,0002018

15%

10%

?2024

16.

2018202463020185,989,678

2018

20242291,021,397165.6512.74140.8010.8311,0632023831794,144207.5515.97176.4213.5710,7772023228930,582171.1013.16145.4411.1910,414

1 20182 2018

20242023630

2024202393,45179,976125,95798,741219,408178,717

?2024

17.

20231231(87,987)35(11,494)(99,446) (41,399)(35)–(41,434) ––406406

(41,399)(35)406(41,028)2024630(129,386)–(11,088)(140,474)18.

BMS202381BMS-Celgene

ABRAXANE

?20172018BMS-Celgene

201723,273,10820231231

??20241231

2023815362,917,000

20231231

?2024

19.

10%50%

10%

2024630202312311,378,872,0001,837,790,000

?2024

20.

2024630120,366,00028,822,000

91,544,000

202463062,576,000

1,250,000,0002024630

412,647,000

15,054,00020246308,154,000

?2024

21.(a) 20242023630

20242023630(i)50,0002023 50,000

(ii)75,0002023 75,000(iii)

2,099,0002023 2,017,000(b)

202420233,7862,914753221,10619,85724,96722,803

22.

?2024

22.

20242023832,886416,830830,821362,3072,06554,523672,446543,464662,774540,8289,6722,636149,24967,690148,23245,823

1,01721,86726,23715,07826,23715,078––1,680,8181,043,062

2024

23.

IFRS

2024630

(i)(iii)(iv)(915,104)(10,395)–811(924,688)(871,156)(12,922)–1,000(883,078)

29,385––(1,286)28,099(349,346)(23,317)–525(372,138)

(22,209)–(2,951)–(25,160)(371,555)(23,317)(2,951)525(397,298)

2023630

(i)(iii)(iv)(831,348)(13,557)–830(844,075)(723,533)(13,107)–650(735,990)

31,086––(1,556)29,530(704,402)(26,664)–(76)(731,142)

(25,166)(1,567)7,376–(19,357)(729,568)(28,231)7,376(76)(750,499)

2024

23.

2024630

(i)(ii)(iii)(iv)103,633–––(1,859)101,7745,712,179–––(1,859)5,710,320

5,278––2,951–8,2292,345,924––2,951–2,348,87511,840,19723,317–––12,448,137

276,729*307,894*––(8,333,605)(23,317)–(2,951)525(8,946,355)

(276,729)*(307,894)*–(2,384)*3,366,255––(2,951)(1,859)3,361,445

?2024

23.

20231231

(i)(ii)(iv)95,207––(2,384)92,8235,805,275––(2,384)5,802,89111,598,68868,687––12,183,311

208,042*307,894*–(7,962,050)(68,687)–(79)(8,549,057)

(208,042)*(307,894)*(2,305)*3,537,327––(2,384)3,534,943

(i)

202463023,317,000202363026,664,000

2024

23.

(ii)

20162307,894,000

307,894,000(iii)

2024

23.

(iv)

24.

20246302023630

?2024

2011201141520154172011201620181272016

2022429201820182021616

202191ADS13

20162024652016

20244262018

2024652018

2024426198747

20191031202012

201910312023615

2024

20101028

2017125201733BeiGene Switzerland GmbH201791

2024

Novartis Pharm AG

2018730

201620162024630

20162016

?2024

GAAP

2024

ADCBRAFB-rafBTKBCLL

PARPADPDNA

DNAPD-11Tpro-B

PD-L1PD-L2PD-1TPFSR/RSLLTTT

附件：公告原文